Warfarin Reversal
Overview
Effective warfarin reversal is a critical aspect of bleeding management, requiring timely and evidence-based decision-making. This module answers key clinical questions on managing warfarin-related bleeding, including the use of Prothrombin Complex Concentrates (PCCs), vitamin K, and other interventions.
Top Questions
- 1. How do I manage a patient with a life-threatening bleed on warfarin?
- 2. What are the considerations for giving PCC before an urgent surgery / procedure?
- 3. Why should I choose PCCs over plasma for warfarin reversal?
- 4. Why is vitamin K important? Why can't I just give PCC?
- 5. If I administer PO/IV vitamin K will this cause the patient to be resistant to warfarin anticoagulation?
- 6. My bleeding patient on warfarin has a history of recent thrombosis. Are PCCs still appropriate?
- 7. When are PCCs potentially contraindicated?
- 8. How do I manage an asymptomatic (non-bleeding) patient with a high INR on warfarin?
- 9. What laboratory tests do I order if a patient on warfarin is bleeding?
- 10. How do I reconstitute and administer PCC?
- 11. References
- 12. Warfarin Reversal Quiz
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