If I administer PO/IV vitamin K will this cause the patient to be resistant to warfarin anticoagulation?
- “Warfarin resistance” (inability to resume oral anticoagulation) is observed in <1% of patients on warfarin administered oral and intravenous vitamin K 2-10 mg (adults of all ages and indications for anticoagulation).
- Denas G, et al. Effectiveness and safety of a management protocol to correct over-anticoagulation with oral vitamin K: a retrospective study of 1,043 cases. J Thromb Thrombolysis (2009) 27:340–347
- Tai C, et al. Management of Supratherapeutic International Normalized Ratio without Bleeding after Warfarin Use: An Evaluation of vitamin K Administration (SUPRA-WAR-K Study). Can J Hosp Pharm. 2017;70(3):207-14)