Understanding VWF Repeated Dosing and FVIII Accumulation

Dr. Jennifer Leung explores factor VIII (FVIII) accumulation in surgical patients receiving repeated doses of von Willebrand factor (VWF) concentrates, focusing on 1:1 ratio. She discusses clinical decision factors in product selection, physiologic relationships between VWF and FVIII, and product ratio implications for bleeding control and thrombosis risk. The session emphasizes the necessity of balancing product efficacy, safety, and logistical considerations in perioperative planning and highlights recent European data showing low thrombotic complication rates, making this a key update for clinicians managing VWD in surgical settings