PCC and FC in Cardiac Surgery
Overview
This module focuses on the role of Prothrombin Complex Concentrates (PCC) and Fibrinogen Concentrate (FC) in managing bleeding during cardiac surgery. It discusses how these agents can correct coagulation deficits more efficiently than plasma, reducing the need for excessive transfusions. Evidence from clinical studies supports their use in improving surgical outcomes by optimizing clot formation and minimizing blood loss. The module also covers dosing strategies and safety considerations.
Top Questions
- 1. What Hemostatic considerations are most important pre and perioperatively specifically in relation to cardiac surgery?
- 2. What products are most commonly utilized within Cardiac Surgery from a bleed management and Hemostasis perspective?
- 3. Why have most hospitals transitioned away from Cryoprecipitate?
- 4. What is the composition of PCC and FC – e.g. Fibryga contains Human fibrinogen (1 g), Fibronectin (2.1mg) and FXIII (585U).
- 5. What are the key differences in the pharmacodynamics between PCC and FC that impact their use in surgical settings?
- 6. What is the evidence and rational for using PCC over FFP in cardiac patients?
- 7. How does use of PCC prevent volume overload whilst rapidly raising plasma levels of vitamin K-dependent clotting factors?
- 8. What does the current evidence show in terms of the number of thrombotic events associated with PCC and FC compared to FFP
- 9. How does the use of PCC and FC support patient blood management?
- 10. When is point-of-care testing (POC) implemented during these surgeries?
- 11. Under what circumstances would factor concentrates (FC) or prothrombin complex concentrate (PCC) be used without the availability of POC testing?
- 12. References
- 13. PCC and FC in Cardiac Surgery Quiz
Recommended Modules
Warfarin Reversal
Effective warfarin reversal is a critical aspect of bleeding management, requiring timely and evidence-based decision-making. This module answers key clinical…
Enroll Now
DOAC Reversal
Managing bleeding in patients on Direct Oral Anticoagulants (DOACs) requires a rapid and informed approach. This module provides guidance on…
Enroll Now
7 Key Parts (7 Ts) of The Massive Hemorrhage Protocol
Massive Hemorrhage Protocol (MHP) is a structured approach to managing severe bleeding by ensuring timely activation, coordinated teamwork, and evidence-based…
Enroll Nowtreatthebleed©2025